Skin Structure & Function

Chapter 1 of Volume 3, Skin, Burns & Surgical Principles. Revision notes for the FRCS (Plast).

What this chapter covers

• Epidermis (~100 μm avg thickness)
• Dermis
• Hypodermis
• Clinical Features
• Cutis Laxa normal wound healing
• Progeria (Hutchinson-Gilford Progeria Syndrome)
• TGF-β Isoforms in Wound Healing
• Hypertrophic Scar
• Keloid Scar
• Pathogenesis
• PTCH Gene Mutation & Sonic Hedgehog Pathway
• Xeroderma Pigmentosum (XP)
• Photodynamic Therapy (PDT)
• Vismodegib – Hedgehog Pathway Inhibitor
• 5-Fluorouracil (5-FU) vs. Imiquimod
• Atypical Mole Syndrome / FAMMM – High-Yield Summary
• Cutaneous Squamous Cell Carcinoma
• Skin Lesions of Dermal Origin (Adnexal Tumours)
• Naevus Sebaceus of Jadassohn
• Sweat Gland Adnexal Tumours
• Rhinophyma
• Sebaceous Carcinoma
• Viral Wart (Verruca Vulgaris)